Psoriasis exacerbation treatment
Tartalom
As both stressor and its effects are subject-dependent, thus extremely difficult to measure, our understanding of the exact role of stress in disease development was limited for a long time. In the past decade several new studies were carried out which expanded our knowledge on the pathophysiologic processes linking stress to psoriasis via with their objective measurements and the applied new techniques. The authors review the current literature of both psychological alexithymia, personality, affect and biological cortisol, epinephrine, neurogenic inflammation factors influencing stress perception and response in psoriasis.
Leírás: Patients will receive 1 subcutaneous SC injection of FYB at week 0 and week 4, followed by 1 SC injection every 12 weeks thereafter for the next 3 consecutive doses. Karcsoport címke: FYB Proposed ustekinumab biosimilar Beavatkozás típusa: Drug Beavatkozás neve: Stelara® Ustekinumab Leírás: Patients will receive 1 subcutaneous SC injection of Stelara® at week 0 and week 4, followed by 1 SC injection every 12 weeks thereafter for the next 3 consecutive doses.
Patients who provided written informed consent and who are able to complete study procedures.
Patients who are at least 18 years of age at time of screening. Patients with PASI score of at least 12 at screening and at baseline.
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Patients with a Physician's Global Assessment PGA score of at least 3 at screening and at baseline by means of a 5-point scoring scale. Patients who are candidates for systemic therapy or phototherapy.
Previous failure, inadequate response in the opinion of the investigator, intolerance, or contraindication to at least 1 conventional antipsoriatic systemic therapy. For female patients except those at least 2 years postmenopausal or surgically sterilised : a negative serum pregnancy pikkelysömör kezelésére spray at screening and at baseline.
Female patients of childbearing potential with a fertile male sexual partner must psoriasis exacerbation treatment adequate contraception from screening until 4 months after the last dose of study intervention. Adequate contraception is defined as using hormonal contraceptives or an intrauterine device IUDcombined with at least one of the following forms of contraception: a diaphragm, cervical cap, or a condom.
A pikkelysömör és a stressz közötti összefüggés pszichológiai és biológiai alapjai
Total abstinence from heterosexual activity, in accordance with the lifestyle of the patient, is acceptable. Female patients must not donate ova starting at screening and throughout the clinical study period and for 4 months after study intervention administration.
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Male patients who are sexually active with women of childbearing potential must agree they will use adequate contraception if not surgically sterilised and will not donate sperm from the time of screening until 6 months after the last dose of study intervention.
Adequate contraception for the male patient and his female partner of childbearing potential is defined as using hormonal contraceptives or an IUD combined with at least one of the following forms of contraception: a diaphragm, cervical cap, or a condom. Exclusion Criteria: 1.
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Patients diagnosed with erythrodermic psoriasis, pustular psoriasis, guttate psoriasis, medication-induced psoriasis, any other skin disease, or other systemic inflammatory autoimmune disorder at the time of the screening and baseline visits that would interfere with evaluations of the effect of study intervention on psoriasis.
Patients who have received any topical psoriasis treatment including corticosteroids. Patients who have received the following treatments for psoriasis: 1.
Psoriasis - How I Deal With and Manage Autoimmune Disease (Diet, Treatment, Body Confidence)
Non-biologic psoriasis systemic therapies, tofacitinib, or apremilast 3. Adalimumab 4.
Etanercept or secukinumab 5. Infliximab, brodalumab, certolizumab pegol, ixekizumab, golimumab, or alefacept 4.
[Psychological and biological background of the correlation between psoriasis and stress]
Patients taking drugs that may cause new onset or exacerbation of psoriasis 5. Patients who have received ustekinumab or any biologics directly targeting interleukin IL 12 or IL Patients with active infection or history of infections as follows: 1.
Any active infection for which systemic anti-infectives were used within 4 weeks prior to randomisation 2. A psoriasis exacerbation treatment infection, defined as requiring hospitalisation or intravenous anti-infectives, within 8 weeks prior to randomisation 3. Evidence of any clinically relevant bacterial, viral, fungal, or parasitic infection 4.
Recurrent or chronic infections or other active infection that, in the opinion of the investigator, might cause this study to be detrimental to the patient Nem:.
